BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
BEGIN:VEVENT
UID:20260207T201833EST-1941lbrDOc@132.216.98.100
DTSTAMP:20260208T011833Z
DESCRIPTION:\n	Title: New Advances in High-Dimensional DNA Methylation Analy
 sis in Cancer Epigenetic Using Trans-dimensional Hidden Markov Models\n\n	 
 \n\n\nAbstract:\n\nEpigenetic alterations are key drivers in the developme
 nt and progression of cancer. Identifying differentially methylated cytosi
 nes (DMCs) in cancer samples is a crucial step toward understanding these 
 changes. In this talk\, we propose a trans-dimensional Markov chain Monte 
 Carlo (TMCMC) approach that uses hidden Markov models (HMMs) with binomial
  emission\, and bisulfite sequencing (BS-Seq) data\, called DMCTHM\, to id
 entify DMCs in cancer epigenetic studies. We introduce the Expander-Collid
 er penalty to tackle under and over-estimation in TMCMC-HMMs. We address a
 ll known challenges inherent in BS-Seq data by introducing novel approache
 s for capturing functional patterns and autocorrelation structure of the d
 ata\, as well as for handling missing values\, multiple covariates\, multi
 ple comparisons\, and family-wise errors. We demonstrate the effectiveness
  of DMCTHM through comprehensive simulation studies. The results show that
  our proposed method outperforms other competing methods in identifying DM
 Cs. Notably\, with DMCTHM\, we uncovered new DMCs and genes in Colorectal 
 cancer that were significantly enriched in the Tp53 pathway.\n\nSpeaker\n
 \nFarhad Shokoohi is currently serving as an Assistant Professor of Statis
 tics in the Department of Mathematical Sciences at the University of Nevad
 a\, Las Vegas (UNLV) since 2019. He obtained his Ph.D. in Statistics from 
 Shahid Beheshti University in Iran in 2012. Following his doctoral studies
 \, Farhad completed three postdoctoral fellowships at the University of Ma
 nitoba (2013) and ºÚÁÏÍø±¬³Ô¹Ï (2013-2014\, 2014-2016). Subsequently\
 , he held the position of Assistant Professor at Concordia University from
  2017 to 2018. Farhad has also held visiting scholar positions at the Univ
 ersity of Perugia\, Italy\, and Ohio State University\, USA.\n\nFarhad’s r
 esearch expertise spans diverse areas of statistical analysis\, including 
 high-dimensional data analysis\, Bayesian and frequentist methods\, machin
 e learning\, statistical genomics and genetics\, computational statistics\
 , and software development\, among other fields.\n\nhttps://mcgill.zoom.us
 /j/83008174313\n\nMeeting ID: 830 0817 4313\n\nPasscode: None\n\n \n
DTSTART:20240112T203000Z
DTEND:20240112T213000Z
LOCATION:Room 1104\, Burnside Hall\, CA\, QC\, Montreal\, H3A 0B9\, 805 rue
  Sherbrooke Ouest
SUMMARY:Farhad Shokoohi (University of Nevada)
URL:/mathstat/channels/event/farhad-shokoohi-universit
 y-nevada-354046
END:VEVENT
END:VCALENDAR