BEGIN:VCALENDAR VERSION:2.0 PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4// BEGIN:VEVENT UID:20260201T151637EST-8369ALHKSk@132.216.98.100 DTSTAMP:20260201T201637Z DESCRIPTION:\nThe Neuro Epilepsy Day 2026: Epilepsy Across Multiple Scales  \n\nThe Neuro Epilepsy Day will be a full-day program\, exploring epilepsy research and treatment across all scales: molecular\, cellular\, circuit\ , and connectome.\n\n\nRegister Now\n\nTo watch online\, click here\n\n\nC all for Abstracts\n\nWe invite undergraduate\, graduate\, and postdoctoral trainees to submit abstracts for poster presentations at The Neuro Epilep sy Day 2026. \n\nWe encourage abstracts at any stage of a project’s develo pment—from literature reviews and research questions to pilot data and ong oing studies.\n\nSubmission deadline: March 23\, 2026\n\nSubmit Your Abstr act Here\n\nSelected abstracts will be featured in the poster session\, an d five outstanding posters will be invited to give a short oral presentati on during the program.\n\n\n\n \n Programme\n Speakers\n The Pierre Gloor Lect ure\n Location\n Sponsors\n Scientific Committee\n \n\n \n Thursday\, May 28\, 2 026\n\n Preliminary Program \n\n \n \n \n 9:15\n \n Arrival & Registration\n \n \n \n 9:30\n \n Lab Tours\n\n Neuroimaging\, EEG/FMRI\, MEG\,\n \n \n \n 10:45\n \n Wel come and Introduction\n\n Boris Bernhardt\, PhD\n Associate Professor of Neu rology and Neurosurgery\n Epilepsy Group Leader (Research)\, The Neuro\n \n \n \n 11:00\n \n Keynote Lectures\n\n Improving Epilepsy Surgery Planning Using MR Fingerprinting\n\n Irene Wang\, PhD\n Research Director and Staff Scient ist\n Cleveland Clinic Epilepsy Center\n\n Networks\n\n Seok-Jun Hong\, PhD\n Associate Professor of Biomedical Engineering Department\, SKKU\n Sungkyunk wan University - Թ\n\n Surgical Approaches and Innovations in FCD\n\n Roy William Dudley\, FRCSC\n Assistant Professor\, Department of Pediatric Surgery\, Department of Neurology & Neurosurgery\n Montreal Child ren's Hospital\n\n Alexander G. Weil\, FRCSC\, FACS\n Associate Professor\, Neurosurgeon\, Researcher\, Director\n University of Montreal - Sainte-Just ine Hospital Research Centre\n\n Jeffery Allan Hall\, FRCSC\n Assistant Prof essor of Neurology and Neurosurgery\n Epilepsy Programme\, Neurosurgery Cli nic\, Brain Tumour Clinic\n\n Sami Obaid\, MD\, PhD\, FRCSC Clinical Assist ant Professor\, Neurosurgeon Department of Surgery\, Faculty of Medicine C entre hospitaliser de l'Université de Montréal\n \n \n \n 1:00\n \n Lunch and Po ster Session\n \n \n \n 2:00\n \n Oral Presentations\n \n \n \n 3:00\n \n Coffee Break \n \n \n \n 3:15\n \n Pierre Gloor Lecture\n\n Brain Mosaicism in Epilepsies and Cortical Malformations\n Stéphanie Baulac\, PhD\n Research director and Grou p Leader\n Inserm and Paris Brain Institute (ICM)\n \n \n \n 4:15\n \n Discussion Panel\n\n Samantha Audrain\, PhD \n\n Alexander Barnett\, PhD \n\n Stéphanie  Baulac\, PhD \n\n Andrea Bernasconi\, MD  \n\n Boris Bernhardt\, PhD \n\n Ne da Ladbon-Bernasconi\, PhD  \n\n Sara Lariviere\, PhD  \n\n Raluca Pana\, MD \, FRCP\, CSCN \n\n Myriam Srour\, MDCM\, PhD \n \n \n \n 5:00\n \n Cocktail Rece ption (onsite)\n \n \n \n \n \n\n \n Speakers\n\n Keynotes:\n\n Irene Wang | Improv ing Epilepsy Surgery Planning Using MR Fingerprinting\n\n Dr. Irene Wang is the Research Director and Full Staff at the Cleveland Clinic Epilepsy Cen ter and an Associate Professor of Neurology at the Cleveland Clinic Lerner College of Medicine. Her research advances surgical treatments for MRI-ne gative epilepsy patients through innovative imaging and neurophysiology te chniques. As a trained biomedical engineer with a strong foundation in cli nical neurophysiology and neuroimaging\, Dr. Wang has pioneered the integr ation of advanced imaging into clinical practice to enhance patient care. She has authored over 120 peer-reviewed papers and serves as Associate Edi tor for Epilepsia. Dr. Wang has received continuous support from the Natio nal Institute of Health and serves as a charter member of the NIH Imaging Technology for Neuroscience study section. Dr. Wang also chairs the MRI Da ta Task Force of the ILAE Big Data Commission and serves on the Imaging Ta sk Force of the ILAE Diagnostic Methods Commission.\n \n Improving Epilepsy Surgery Planning Using MR Fingerprinting\n\n This talk will focus on MR Fin gerprinting (MRF)\, a novel quantitative MRI technique that enables simult aneous acquisition of multiple tissue parameters within a single\, time-ef ficient acquisition\, providing a comprehensive multiparametric characteri zation of brain tissue properties. The talk will include clinical examples and studies demonstrating the added value of MRF for detection and subtyp e characterization of focal cortical dysplasia\, including cases with subt le or nonlesional findings on conventional MRI. The talk will further expl ore the potential of MRF-derived tissue metrics to inform in vivo epilepto genicity in more complex malformations of cortical development\, such as p eriventricular nodular heterotopia and polymicrogyria. Together\, these ex amples illustrate how MRF can enhance presurgical localization\, optimize SEEG implantation\, and improve prognostication for epilepsy surgery candi dates.\n\n  \n\n Stéphanie Baulac | Pierre Gloor Lecture\n\n Stéphanie Baulac is a Research Director at Inserm and Group Leader at the Paris Brain Inst itute (ICM) of the MOSAIC Team « Genetic Mosaicism in Epilepsy and Neurode velopmental Disorders » Her team implements a comprehensive translational approach spanning from the identification and characterization of somatic mutations in brain tissues obtained from patients undergoing epilepsy surg ery to in-depth functional analysis\, combining functional testing on pati ent-derived brain organoids\, and mouse models. \n \n Brain Mosaicism in Epi lepsies and Cortical Malformations\n Focal cortical dysplasia type II (FCDI I) is a cortical malformation causing refractory epilepsy\, resulting from developmental somatic mutations in mTOR pathway genes. To understand how these mutations create a mosaic pattern of affected cells and lead to cort ical dyslamination\, we performed comprehensive single-nucleus analyses of surgical samples from genetically-characterized FCDII patients. By combin ing genotyping and transcriptomics at single-cell resolution\, we revealed that mutations predominantly affect glutamatergic neurons and astrocytes\ , creating distinct transcriptional programs in both mutated and non-mutat ed cells. This mosaicism drives cell-type-specific dysregulation of synapt ic and neurodevelopmental pathways that likely contribute to epileptogenes is. Notably\, our analysis of cytomegalic cells uncovered pronounced alter ations in mitochondrial metabolism pathways and cellular senescence. We un cover a signature associated with cellular senescence in abnormal FCDII ce lls and further provide evidence in preclinical FCDII mouse models that se nolytic agents could offer a novel therapeutic strategy for this disorder. \n\n  \n\n Seok-Jun Hong\n\n Seok-Jun Hong\, PhD is an associate professor in the Department of Biomedical Engineering\, and Brain Science and Engineer ing at Sungkyunkwan University (SKKU) and also affiliated with the Center for Neuroscience Imaging Research\, IBS in S. Korea. Before joining to SKK U\, he was a postdoctoral research fellow in Child Mind Institute at New Y ork\, working with Drs. Michael Milham and Adriana Di Martino\, and before that\, in MNI with Dr. Boris Bernhardt. Dr. Hong’s previous research has focused on advanced in-vivo multimodal magnetic resonance imaging of typic al and atypical brain development (epilepsy and autism)\, especially targe ting a large-scale brain network organization. Building upon expertise in computer science\, statistics and neuroinformatics\, he has developed orig inal approaches to quantitatively describe connectome principles and its d evelopmental process in the human brain. These days\, his interest is how to inform biological inductive biases learned from the human brain to buil d up large-scale biophysical neural network models.\n\n  \n\n Sami Obaïd | S urgical approaches and innovations in FCD\n\n - Dr. Sami Obaïd\, M.D.\, Ph .D.\, is a neurosurgeon specializing in epilepsy at the Centre hospitalier de l’Université de Montréal (CHUM) and a Clinical Assistant Professor in the Department of Surgery at the Université de Montréal. He is also a prin cipal investigator at the CHUM Research Centre (CRCHUM)\, where he leads t he ONSET lab. His surgical practice is dedicated to epilepsy surgery\, and in 2024\, he was awarded the prestigious FRQS Junior 1 Researcher status. He underwent specialized training\, including a fellowship in epilepsy su rgery at Yale University and a Ph.D. in structural neuroimaging applied to focal epilepsy. Dr. Obaïd focuses his clinical and scientific activities on the identification\, selection\, presurgical evaluation\, operative and postoperative management of patients with drug-resistant epilepsy through innovative neuroimaging techniques. Recognized early for his contribution s to research\, an asteroid was named in his honor: the minor planet Obaïd (21712). He has also been named a Distinguished Citizen of Canada for his scientific achievements\, listed among the “Top 20 Under 20”\, and one of his articles was awarded Discovery of the Year 2022 at the CRCHUS. He rec ently had the honor of serving as a guest co-speaker alongside astronaut C hris Hadfield\, reflecting the reach of his work and his commitment to sci ence communication. A few months ago\, he also signed the Golden Book of t he King of Morocco in recognition of his academic and scientific accomplis hments. At the ONSET laboratory\, Dr. Obaïd currently supervises 22 gradua te students and two research assistants\, actively contributing to the tra ining of the next generation of neuroscientists.\n\n  \n\n Roy Dudley | Asso ciate Professor\, Թ Health Centre\n\n Roy Dudley MD\, PhD i s a an Associate Professor at Թ and a Pediatric Neurosurge on at the Montreal Children's Hospital and the Montreal Neurological Hospi tal. He did his undergraduate studies in Biology and Mathematics at Memori al University of Newfoundland\, and his PhD in Experimental Medicine at Mc Gill and the MNI with the late George Karpati. He returned to Newfoundland for Medical School and came back to the MNI for Neurosurgery residency un der the epilepsy surgery tutelage of Jeffery Hall and Andre Olivier. He th en did his Pediatric Neurosurgery Fellowship at the University of Colorado in Denver. Dr. Dudley specializes in epilepsy surgery and is an FRSQ-spon sored clinical investigator with research program focused on optimizing th e presurgical evaluation of focal epilepsy patients using advanced neuroim aging and electrophysiology\, improving the intraoperative localization of malformations of cortical development\, such as focal cortical dysplasia\ , and overcoming the limitation of spatial coverage with SEEG.\n\n Novel Me thods in SEEG to Optimize Epileptogenic Zone Localization and Functional M apping: Overcoming the Limitation of Spatial Coverage\n\n Surgical treatmen t of refractory focal epilepsy can be curative and should be considered as early as possible\, particularly in children. In challenging (usually MRI -negative) cases\, an intracerebral investigation via stereo-EEG (SEEG) is often necessary to localize the epileptogenic zone (EZ). Despite advanced neuroimaging/electrophysiology techniques and robotic technology\, the ou tcome of SEEG has improved little in 70 years\, the main drawbacks being t he often-ill-informed pre-implantation hypotheses and the sparse coverage of the brain\, resulting in under-sampling or completely missing the EZ an d/or its borders\, and suboptimal stimulation for functional mapping. Our ongoing research aims to overcome these drawbacks of SEEG by (1) improving the pre-implantation hypothesis using novel methods in magnetoencephalogr aphy (MEG)\, such as virtual electrodes\, (2) optimizing SEEG signal analy sis via simultaneous MEG/SEEG\, and (3) refining SEEG-based functional map ping via novel analysis (i.e.\, video/SEEG correlates) of spontaneous move ments and optimizing the stimulation parameters used to illicit ictal vers us normal responses.\n\n \n \n\n \n The Pierre Gloor Lecture\n\n The Pierre Glo or Lecture celebrates the life and legacy of Pierre Gloor (1923–2003)\, wh o joined The Neuro (Montreal Neurological Institute-Hospital) in 1952 as a fellow in electroencephalography and neurophysiology. He trained under Wi lder Penfield and Herbert Jasper and earned his PhD from Թ in 1957. Gloor collaborated closely with clinical and research teams at T he Neuro in advancing the understanding and treatment of epilepsy\, gainin g international recognition for his contributions to the field.\n\n Brain M osaicism in Epilepsies and Cortical Malformations\n\n Speaker: Stéphanie Ba ulac\, PhD\n Research director and Group Leader\n Inserm and Paris Brain Ins titute (ICM)\n\n Focal cortical dysplasia type II (FCDII) is a cortical mal formation causing refractory epilepsy\, resulting from developmental somat ic mutations in mTOR pathway genes. To understand how these mutations crea te a mosaic pattern of affected cells and lead to cortical dyslamination\, we performed comprehensive single-nucleus analyses of surgical samples fr om genetically-characterized FCDII patients. By combining genotyping and t ranscriptomics at single-cell resolution\, we revealed that mutations pred ominantly affect glutamatergic neurons and astrocytes\, creating distinct transcriptional programs in both mutated and non-mutated cells. This mosai cism drives cell-type-specific dysregulation of synaptic and neurodevelopm ental pathways that likely contribute to epileptogenesis. Notably\, our an alysis of cytomegalic cells uncovered pronounced alterations in mitochondr ial metabolism pathways and cellular senescence. We uncover a signature as sociated with cellular senescence in abnormal FCDII cells and further prov ide evidence in preclinical FCDII mouse models that senolytic agents could offer a novel therapeutic strategy for this disorder.\n\n  \n\n \n \n\n \n Loc ation\n\n The Montreal Neurological Institute and Hospital is at 3801 Unive rsity Street\, north of Pine Avenue West\, on the Թ campus opposite the former Royal Victoria Hospital.\n\n Montreal is served by hig hway Routes 10\, 15\, 20 and 40\, and by Greyhound Bus\, Via Rail and the P-E-Trudeau airport. In the city\, bus and metro service is provided by th e Société de transport de Montréal (STM).\n\n Wheelchair access\n\n A wheelc hair accessible entrance is on University Street north of the main entranc e. Another wheelchair accessible entrance is in the loading area behind th e building: to enter the loading area\, turn into the driveway south of th e main entrance. Please note\, there is no parking in the loading area.\n \n Parking\n\n Parking near the MNI is sometimes difficult. There are parkin g meters on University Street and a parking lot north of the main entrance . To enter the lot\, turn right into the driveway toward Molson Stadium.\n \n Information about parking fees\n\n Taxi Stand\n\n There is a taxi stand on University Street across from the main entrance. You may call a cab from the free taxi phone in the main lobby near the Security Desk.\n\n Access by Public Transportation (STM website)\n\n Bus\n\n There are four bus stops wi thin walking distance:\n\n \n Bus 144 stops at Pine Avenue and University St reet\n Bus 356 stops at Sherbrooke Street and University Street (Nightbus) \n Bus 107 stops at Pine Avenue and Docteur Penfield\n Bus 24 stops at Sherb rooke Street and University Street\n \n\n Metro\n\n Take the Metro Green Line to the Թ station. Walk north on University Street and cross Pine Ave nue. The main entrance is on the right\, past the flags.\n\n Jeanne Timmins Amphitheatre\n\n \n Enter the main lobby\, turn left\, and go down the hall way to the end.\n Turn right and go down the second hallway until you see a nother hallway on the left.\n This hallway leads to the Jeanne Timmins Foye r.\n On your right are the Jeanne Timmins Amphitheatre entrance doors.\n \n \n\n \n Sponsors \n \n\n \n Scientific Committee\n\n Sam Audrain\n\n Alexander Ba rnett\n\n Boris Bernhardt\n\n Sara Larivière\n\n Raluca Pana\n\n Debbie Rashco vsky\n\n Myriam Srour\n\n  \n\n \n \n\n DTSTART:20260528T131500Z DTEND:20260528T210000Z LOCATION:Jeanne Timmins Amphitheatre\, The Neuro SUMMARY:The Neuro Epilepsy Day 2026: Epilepsy Across Multiple Scales URL:/neuro/channels/event/neuro-epilepsy-day-2026-epil epsy-across-multiple-scales-368975 END:VEVENT END:VCALENDAR