/tropmed/aggregator J.D. MacLean Centre for Tropical & Geographic Medicine - aggregated feeds en https://pubmed.ncbi.nlm.nih.gov/41629481/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20260203015657&v=2.18.0.post22+67771e2 Antimicrobial susceptibility testing (AST) technologies that rapidly identify pathogenic bacteria and their resistance phenotypes are critical in addressing the antimicrobial resistance crisis, enabling timely and precise antibiotic treatment decisions. We present a modular automated platform based on nanoplasmonic colorimetry in microfluidics for parallel bacterial identification and phenotypic profiling of AST (QolorPhAST), achieving an eightfold enhancement in detection rapidity. QolorPhAST... Mon, 02 Feb 2026 06:00:00 -0500 https://pubmed.ncbi.nlm.nih.gov/41627767/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20260203015657&v=2.18.0.post22+67771e2 In vitro enzyme assays provide sensitive and quantitative approaches to studying activity, identifying substrates or performing inhibitor analysis. These approaches can help to study enzymes that regulate different cellular processes in an organism. In addition, enzyme assays can be used to screen protein inhibitors to identify novel drug candidates. In eukaryotes, phosphatidylinositol kinase and phosphatase are enzymes that regulate the level of phosphorylated phosphatidylinositol, which... Mon, 02 Feb 2026 06:00:00 -0500 https://pubmed.ncbi.nlm.nih.gov/41611368/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20260131002227&v=2.18.0.post22+67771e2 BACKGROUND: Tuberculosis elimination requires expanded use of preventive treatment. However, adherence to the tuberculosis infection cascade of care is often an issue, notably in vulnerable groups such as migrants. We aimed to assess a person-centred approach to tuberculosis screening and treatment using facilitators, comparing strategies for tuberculosis prevention among new migrants to Canada. Thu, 29 Jan 2026 06:00:00 -0500 https://pubmed.ncbi.nlm.nih.gov/41591385/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20260128005218&v=2.18.0.post22+67771e2 CONCLUSIONS AND RELEVANCE: In this cross-sectional study of travelers' diarrhea antimicrobial resistance patterns, there was marked variability of nonsusceptibility to 2 major classes of antibiotics commonly used for treating travelers' diarrhea among global regions. Antimicrobial susceptibility from culture should be obtained when possible, including after pathogen detection by culture-independent methods. These findings may help inform strategies for self-treatment and clinician management of... Tue, 27 Jan 2026 06:00:00 -0500 https://pubmed.ncbi.nlm.nih.gov/41567488/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20260123003256&v=2.18.0.post22+67771e2 CONCLUSION: Thus, CBHM-Ferlo strategy improved the care of childhood illness in Matam in 2024, and above all highlights the added value of One Health and transdisciplinary approaches. Thu, 22 Jan 2026 06:00:00 -0500 https://pubmed.ncbi.nlm.nih.gov/41558254/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20260122023405&v=2.18.0.post22+67771e2 Due to climate change and human interventions, there has been an increase in D. immitis infections, underscoring the necessity for monitoring the spread and extent of resistance. In our prior research, we introduced a rapid test utilizing four predominant SNP markers at loci 15709 (SNP1), 30575 (SNP2), 21554 (SNP3), and 9400 (SNP7) linked to ML resistance. Our findings highlighted SNP1 and SNP2 as potent predictive markers, offering suitability for the rapid detection and monitoring of drug... Tue, 20 Jan 2026 06:00:00 -0500 https://pubmed.ncbi.nlm.nih.gov/41512448/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20260110003316&v=2.18.0.post22+67771e2 CONCLUSIONS: An evaluation of pharmacovigilance data from 2 different sources revealed no evidence of greater proportional reporting for neurological AEs specific to the use of eprinomectin-containing products in cats than for other MLs or emodepside. Fri, 09 Jan 2026 06:00:00 -0500 https://pubmed.ncbi.nlm.nih.gov/41408357/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20251218015104&v=2.18.0.post22+67771e2 BACKGROUND: As the result of systemic and structural barriers, hepatitis C virus (HCV) continues to disproportionately affect people who inject drugs, those in prison, Indigenous peoples, immigrants from HCV-endemic countries, and gay, bisexual and other men who have sex with men in Canada. Point-of-care antibody and RNA testing improve access to HCV testing and enable single-visit diagnosis and treatment initiation, yet robust, context-specific strategies are needed to scale these technologies... Wed, 17 Dec 2025 06:00:00 -0500 https://pubmed.ncbi.nlm.nih.gov/41407521/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20251218015104&v=2.18.0.post22+67771e2 Trypanosoma cruzi, the causative agent of Chagas disease, poses a significant health challenge due to limited therapeutic options and an incomplete understanding of its biology. Approximately half of the genome encodes hypothetical proteins with unknown functions, underscoring the need for systematic functional annotation. Protein-protein interactions (PPIs) underpin essential cellular processes, yet no large-scale PPI map has been developed for T. cruzi ─a critical gap that impedes both... Wed, 17 Dec 2025 06:00:00 -0500 https://pubmed.ncbi.nlm.nih.gov/41389704/?utm_source=Other&utm_medium=rss&utm_campaign=pubmed-2&utm_content=1zSVwQViw4htk0ptJE-rdb4g98Hn0Vy51ceCnixBnFkL6ILsbf&fc=20201106102241&ff=20251214014828&v=2.18.0.post22+67771e2 CONCLUSIONS: These findings suggest that sex may not be a major factor in vaccine response in pediatric populations, but may be more likely to be detected in influenza vaccine trials with a non-influenza vaccine control group. Sat, 13 Dec 2025 06:00:00 -0500