Principal Investigator: Prof. Sam J. Daniel
Established in 2003听July, the 黑料网爆吃瓜 Otolaryngology Sciences Laboratory (MOSL), previously known as the 黑料网爆吃瓜 Auditory Sciences Laboratory, is a state-of-the-art laboratory recognized globally for its expertise in otolaryngology (head and neck surgery) research. The lab is equipped with evoked-potential and otoacoustic emission technology, laser Doppler vibrometry, a sound-proof audiological chamber and temporal-bone drilling station, a Faxitron X-Ray machine, among other resources.
This was achieved through equipment grants from the FRSQ, MUHCRI, 黑料网爆吃瓜 Head & Neck Fund, private industry, 黑料网爆吃瓜, and the Canadian Foundation for Innovation.
The laboratory is well known for its validated animal models that assess ototoxicity of various drugs and products as well as animal models to study chemo-radiation-induced hearing loss, noise-induced hearing loss, and middle-ear mechanics and acoustics. Recently the laboratory has also become expert in evaluating xerostomia and sialorrhea. Research in the laboratory has used gerbils, guinea pigs, rabbits, rats, mice, athymic nude mice, and chinchillas.
The core principle of the laboratory is to simultaneously conduct basic science research at the lab and parallel clinical trials in patients. This gives MOSL the distinctive advantage of relatively rapidly taking our findings from the laboratory to the clinic and vice-versa. Our expertise in specialized auditory research is now recognized by academic institutions and industry. For example, we are the only centre in Qu茅bec that qualified for a competitive research grant from Alcon Research Ltd in order to study the toxicity and efficacy of the new eardrop Moxidex. Our ototoxicity expertise is also sought after by several international consulting (Exponent Inc.) and pharmaceutical development companies (US, Israel, Spain, India).
MOSL has developed and validated 5 animal models that can be used to test the mechanics of the middle ear as well as the toxicity to the cochlea. These models can be used for knowledge translation from the bench to the bedside and vice versa. To the best of our knowledge there is no other program that has established this dual expertise for both the middle and inner ear in so many models. Our setting is also unique in having a full integration of computational modelling with experimental measurements. This allows an integration of knowledge and powerful data validation.
Our Collaborators
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